glucagon-like peptide-1 (GLP-1) secretion and abrogated by the administration of Exendin(9-

ORIGINAL RESERCH ARTICLE 1 TITLE: Dual actions of a novel bifunctional compound to lower glucose in mice with diet2 induced insulin resistance 3 4 AUTHORS: 5 Katherine Chen, Alice Jih, Sarah Kavaler, William S. Lagakos, Dayoung Oh, Steve 6 Watkins, and Jane J. Kim 4 7 8 Departments of Pediatrics and Medicine, University of California at San Diego, La Jolla, 9 California, USA 10 Metabolon, Durham, North Carolina, USA 11 Rady Children’s Hospital of San Diego, California, USA 12 13 Running head: Dual actions of a novel compound to lower glucose 14 15 Corresponding Author: 16 Jane J. Kim, MD 17 9500 Gilman Drive, MC 0673 18 University of California, San Diego 19 La Jolla, CA 92093-0673 20 Tel: (858) 534-8228 21 Fax: (858) 534-6653 22 Email: [email protected] 23 Articles in PresS. Am J Physiol Endocrinol Metab (June 9, 2015). doi:10.1152/ajpendo.00045.2015